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L-Methylfolate (15 mg) Plus Methyl-B12

L-Methylfolate (15 mg) Plus Methyl-B12

 (Rated 4.9/5 based on +1475 reviews)
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Key Ingredients

  • Folate
  • Vitamin B12
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Size / Suggested Use

  • Size: 1 oz - 60 Servings
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Product Details

  • Absorbs directly into the bloodstream and requires no processing from the body.
  • Contains the essential Cofactor MethylB12.
  • Supports brain and heart health and contributes to balancing energy, hormones, and mood

L-Methylfolate is the biologically active, bloodstream-ready form of Folate (Vitamin B9). Our formulation provides a maximum strength dose of 15 mg L-Methylfolate. This strength was formulated to support optimal folate levels. The formula also includes a whole serving of Methyl-B12, an essential cofactor to L-Methylfolate. The liquid sublingual form provides enhanced absorption and an enjoyable cherry flavor. It also contributes to the production of neurotransmitters, which are involved in maintaining focus, regulating sleep patterns, providing energy, balancing hormones, and impacting mood. Furthermore, Methylfolate promotes heart health and optimal nerve function.*

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Methylated Folate: A Nutrient Form Some People Prefer for Genetic Support*

Certain MTHFR gene variations may affect how the body processes synthetic folic acid. Methylated forms like 5-MTHF can offer a more direct form of folate support.Methylated vitamins provide folate in a body-ready form, supporting bioavailability and cellular use.*

Why You’ll Love Our L-Methylfolate

Bloodstream Ready L-Methyfolate*

Designed for Efficient Absorption*

No Conversion Required - Body-Ready Form*

Enhanced with B12*

  • Supports neurotransmitters like serotonin, dopamine .*

  • Supports red blood cells production and detox in the body.*

  • Helps your homocysteine levels stay in check which is vital for heart and brain health.*

    Body-Ready Nutrients in One Easy Dose

    Supports Mood & Cognition*

    Supports Healthy Methylation*

    Supports Heart Health*

    Supports Nerve Cognition*

        • 3-7 Days: Gradual Support*

          Some individuals may begin to notice support for mental clarity, mood balance, and energy. This is also when nutritional support for red blood cell formation and homocysteine metabolism may begin.*

        • Weeks 4-8: Noticeable Support*

          Neurotransmitter production for the ‘feel good’ hormones like serotonin & dopamine goes up which can help with an improvement in mood and a reduction in symptoms of anxiety.*

        • Month 3-6: Ongoing Support*

          Some individuals may notice more consistent energy levels and support for healthy eating patterns. Users have also shared feeling more in tune with their overall wellness goals and daily routines.*

          Hear From Our Experts

          "As a health researcher, I view L-Methylfolate as an essential nutrient for neurological, emotional, and metabolic balance—especially in individuals with genetic variants like MTHFR. Triquetra’s L-Methylfolate line stands out for its clinically relevant dosing, exceptional purity, and highly bioavailable formulas, with options tailored for both adults and children. It’s a science-backed choice for those seeking therapeutic efficacy and uncompromising quality."

          Adriano Zanardi da Silva, M.Sc., Ph.D

          Frequently Asked Questions

          What is L-Methylfolate and how is it different from folic acid?

          L-Methylfolate is the active form of folate that your body can use immediately. Folic acid needs to be converted—and some people can’t do that well because of genetic mutations like MTHFR.

          What is Methyl B12 and why is it paired with L-Methylfolate?

          Methyl B12 (aka Methylcobalamin) is a highly bioavailable form of B12 that works synergistically with L-Methylfolate to support brain health, energy, and mood.

          Is this product safe if I’m pregnant or breastfeeding?

          Check with your doctor first. L-Methylfolate is often recommended during pregnancy, but always confirm with your healthcare provider.

          Can this supplement interact with medications?

          It is possible L-Methylfolate may interact with certain medications. It is always best to check with a healthcare provider before starting any supplements.

          Are there any known side effects?

          Most people tolerate it well. If you feel like you are sensitive to higher doses, you can work your way up to the full dose over time.


          How do I take it — with food or without?

          It can be taken with or without food, but some people prefer it with a meal to avoid mild stomach discomfort.